Effect of phenylepherine on spinal block for cesarean section.

Completed

• Conditions: Sequelae of complication of pregnancy, childbirth, and the puerperium,

• Registration Number: CTRI/2015/10/006242
• Lead Sponsor: University College of Medical Sciences and GTB Hospital

Brief Summary

Post-spinalhypotension is a major concern during cesarean section following its adversematernal and fetal consequences. Phenylephrine is now well established asa first line of vasopressor for management of post-spinal hypotension inobstetric patients. There is someevidence to show that phenylephrine infusion when used for prevention of thepost-spinal hypotension, as compared to ephedrine, results in a decreasedrostral spread of intrathecal plain levo bupivacaine and hyperbaricbupivacaine. Thedecreased spread of intrathecal hyperbaric bupivacaine did not translate to anincrease in its dose requirement. For intrathecal plain bupivacaine thereis no existing study evaluating whether phenylephrine infusion alters its dose requirement. the present studyaims to evaluate the dose requirement of intrathecal plain bupivacaine forelective cesarean section, with and without phenylephrine infusion.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-01-07
• Study Completion: 2015-10-29
• Last Update Posted: 2021-06-07

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 36

Inclusion Criteria

ASA physical status I or II and an uncomplicated singleton pregnancy of 37 weeks or greater gestation undergoing elective LSCS will be included.

Exclusion Criteria

Patients with extremes of height or weight (body mass index <20 kg/m2 or >35 kg/m2, height <145 cm or >180 cm),those who refuse consent, or with pregnancy induced hypertension, history of diabetes mellitus, cardiovascular or cerebrovascular diseases, fetal abnormalities or any contraindication to combined spinal epidural block will also be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The dose of intrathecal plain bupivacaine	After Sub-arachnoid block, the spinal block both sensory and motor characteristics will be assessed at every 3 minutes for 15 minutes for adequacy of intrathecal dose

Secondary Outcome Measures

Name	Time	Method
Umbilical artery pH and Apgar scoring	Umbilical Artery pH at birth.

Trial Locations

Locations (1)

UCMS & GTB Hospital; 🇮🇳 East, DELHI, India

UCMS & GTB Hospital

🇮🇳East, DELHI, India

Dr Asha Tyagi

Principal investigator

9818606404

drashatyagi@gmail.com