The Effect of Recruitment Maneuver With Protective Ventilation on the Pulmonary and Systemic Inflammatory Response to One-lung Ventilation

Seoul National University Hospital1 site in 1 country60 target enrollmentJune 2012

ConditionsMechanical Ventilation Complication Thoracic Surgery Inflammation

Overview

Phase: N/A
Intervention: Not specified
Conditions: Mechanical Ventilation Complication
Sponsor: Seoul National University Hospital
Enrollment: 60
Locations: 1
Primary Endpoint: Levels of IL-8, TNFa in the bronchoalveolar lavage
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to determine if a recruitment maneuver combined with protective ventilatory strategy could reduce the pulmonary and systemic inflammatory responses to one-lung ventilation during thoracic surgery.

Registry

clinicaltrials.gov

Start Date

June 2012

End Date

May 2014

Last Updated

10 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Seoul National University Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•20 Years and older
•Patients undergoing thoracic surgery

Exclusion Criteria

•Emergency surgery
•Heart failure
•Pulmonary hypertension
•Forced vital capacity or forced expiratory volume in 1 sec \< 50% of the predicted values
•Coagulation disorder
•Pulmonary or extrapulmonary infections
•History of treatment with steroid in 3 months before surgery
•History of recurrent pneumothorax
•History of lung resection surgery

Outcomes

Primary Outcomes

Levels of IL-8, TNFa in the bronchoalveolar lavage

Time Frame: up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery

Secondary Outcomes

plasmatic concentration of inflammatory mediators IL-1, IL-6, IL-8, IL-10, TNFa(up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery)
oxygenation(1 hour after extubation)
Levels of IL-1, IL-6, IL-10 in the bronchoalveolar lavage(up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery)
Chest-X ray(7 days after surgery)