The Effect of Recruitment Maneuver With Protective Ventilation During Thoracic Surgery
Not Applicable
Completed
- Conditions
- Mechanical Ventilation ComplicationThoracic SurgeryInflammation
- Registration Number
- NCT01630395
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
The purpose of this study is to determine if a recruitment maneuver combined with protective ventilatory strategy could reduce the pulmonary and systemic inflammatory responses to one-lung ventilation during thoracic surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- 20 Years and older
- Patients undergoing thoracic surgery
Exclusion Criteria
- Emergency surgery
- Heart failure
- Pulmonary hypertension
- Forced vital capacity or forced expiratory volume in 1 sec < 50% of the predicted values
- Coagulation disorder
- Pulmonary or extrapulmonary infections
- History of treatment with steroid in 3 months before surgery
- History of recurrent pneumothorax
- History of lung resection surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Levels of IL-8, TNFa in the bronchoalveolar lavage up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery
- Secondary Outcome Measures
Name Time Method plasmatic concentration of inflammatory mediators IL-1, IL-6, IL-8, IL-10, TNFa up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery oxygenation 1 hour after extubation Changes in PaO2/FIO2 ratio
Levels of IL-1, IL-6, IL-10 in the bronchoalveolar lavage up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery Chest-X ray 7 days after surgery
Trial Locations
- Locations (1)
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Seoul National University Hospital🇰🇷Seoul, Korea, Republic of