NCT01630395已完成不适用
The Effect of Recruitment Maneuver With Protective Ventilation on the Pulmonary and Systemic Inflammatory Response to One-lung Ventilation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Levels of IL-8, TNFa in the bronchoalveolar lavage
研究概览
简要总结
The purpose of this study is to determine if a recruitment maneuver combined with protective ventilatory strategy could reduce the pulmonary and systemic inflammatory responses to one-lung ventilation during thoracic surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •20 Years and older
- •Patients undergoing thoracic surgery
排除标准
- •Emergency surgery
- •Heart failure
- •Pulmonary hypertension
- •Forced vital capacity or forced expiratory volume in 1 sec < 50% of the predicted values
- •Coagulation disorder
- •Pulmonary or extrapulmonary infections
- •History of treatment with steroid in 3 months before surgery
- •History of recurrent pneumothorax
- •History of lung resection surgery
结局指标
主要结局
Levels of IL-8, TNFa in the bronchoalveolar lavage
时间窗: up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery
次要结局
- plasmatic concentration of inflammatory mediators IL-1, IL-6, IL-8, IL-10, TNFa(up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery)
- oxygenation(1 hour after extubation)
- Levels of IL-1, IL-6, IL-10 in the bronchoalveolar lavage(up to 20 minutes, after reexpansion of the non-dependent lung at the end of surgery)
- Chest-X ray(7 days after surgery)
研究者
研究点 (2)
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