Dopaminergic Enhancement of Learning and Memory in Aphasia
- Conditions
- Cerebrovascular AccidentAphasia
- Registration Number
- NCT00102869
- Lead Sponsor
- University Hospital Muenster
- Brief Summary
The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
- Detailed Description
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether daily administration of levodopa, coupled with several hours of language training every day, will significantly improve naming abilities in patients with aphasia as compared to placebo administration. We furthermore examine with magnetic resonance imaging which brain regions need to be functionally intact for a dopaminergic improvement of language therapy.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 12
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Boost in naming performance (percent correct) through levodopa as compared to placebo immediately after each treatmentphase Brain activity pattern in successfully trained patients immediately after each treatmentphase
- Secondary Outcome Measures
Name Time Method Stability of naming performance after one month and six months post treatment from 1 month untill 6 months after treatment completion
Trial Locations
- Locations (1)
Dept. of Neurology, University Hospital Muenster
🇩🇪Muenster, Nordrhein-Westfalen, Germany