Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Aphasia)
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Cerebrovascular Accident
- Sponsor
- University Hospital Muenster
- Enrollment
- 12
- Locations
- 1
- Primary Endpoint
- Boost in naming performance (percent correct) through levodopa as compared to placebo
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.
Detailed Description
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether daily administration of levodopa, coupled with several hours of language training every day, will significantly improve naming abilities in patients with aphasia as compared to placebo administration. We furthermore examine with magnetic resonance imaging which brain regions need to be functionally intact for a dopaminergic improvement of language therapy.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Boost in naming performance (percent correct) through levodopa as compared to placebo
Time Frame: immediately after each treatmentphase
Brain activity pattern in successfully trained patients
Time Frame: immediately after each treatmentphase
Secondary Outcomes
- Stability of naming performance after one month and six months post treatment(from 1 month untill 6 months after treatment completion)