Improved Language Acquisition With Levodopa
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Boost in language learning success through levodopa compared to placebo
研究概览
简要总结
The purpose of this study is to determine whether the non-daily administration of levodopa is effective in boosting semantic language acquisition in healthy subjects.
详细描述
Our prior work using a between-subject design shows that daily administration of d-amphetamine or the dopamine precursor levodopa over the course of five days markedly improves word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether the effect can be replicated using a within-subject design, with administration of levodopa and placebo on alternate days for a total period of 10 days.
The expected scientific results will strengthen the basis for transferring neuromodulatory interventions from the laboratory to stroke patients with language dysfunctions. Because of the heterogeneity of stroke patients, only a within-subject design can be used to probe the effects of pharmacological adjuncts to language therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects
- •20-35 years old
- •Right handedness
排除标准
- •Neurological/psychiatric/metabolic/cardiac disorders
- •Known allergic reactions to one of the experimental drugs
- •Other drugs affecting the central nervous system
- •Leisure drug ingestion during the past 4 weeks (urine test)
- •Smoking cessation during the past 2 weeks
- •> 6 cups of coffee or energy drinks per day
- •> 10 cigarettes per day
- •> 50 grams of alcohol per day
结局指标
主要结局
Boost in language learning success through levodopa compared to placebo
次要结局
- Stability of language learning success after one month