Comparison of Clomiphene and Letrozole in association with Metfomin in patients with anovulatio

Phase 3

• Conditions: Infertility.; Polycystic ovarian syndrome

• Registration Number: IRCT138807262604N1
• Lead Sponsor: Research and clinical center for infertility, Shahid Sadoughi university of medical sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

polycystic ovary syndrome, Clomiphene resistant, normal liver function, normal kidney function, normal thyroid function. Exclusion criteria: use of Clomiphene in previous 2 months, use of metformin in previous 2 months.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endometrial thickness on day of HCG administration. Timepoint: one time in each cycle. Method of measurement: distance between two layer endometrium measured by sonography.;Estrogen level on day of HCG administration. Timepoint: one time in each cycle. Method of measurement: measurement of estrogen in serum.;Number of follicles>18mm. Timepoint: every other day from cycle day 12. Method of measurement: by counting of follicles more than18 millimeter in sonography.;Chemical pregnancy. Timepoint: 2 weeks after IUI. Method of measurement: by measurement of HCG level in serum.;Clinical prgnancy. Timepoint: one time in each cycle. Method of measurement: observation of gestational sac in sonography.

Secondary Outcome Measures

Name	Time	Method
Abortion rate. Timepoint: one time in each treatment cycle. Method of measurement: observation of expulsion of product of conception from uterous, disappearance of gestational sac in sonography, HCG level in serum dropped or become negative.