Assessment of Left Ventricular Myocardial Dysfunction in Children With End-Stage Kidney Disease Using Two-Dimensional and Three-Dimensional Speckle-Tracking Echocardiography
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Left ventricular systolic function
研究概览
简要总结
The present study aimed to assess left ventricular myocardial dysfunction in children with chronic kidney disease using 2D and 3D speckle-tracking echocardiography.
详细描述
Chronic kidney disease (CKD) is a complex and multifaceted disease that causes renal dysfunction and progression to end-stage kidney disease.
Cardiovascular risk is common in patients with end-stage renal disease on hemodialysis, many studies have shown that the risk of adverse cardiovascular events is significantly increased and persistent in all patients treated with hemodialysis, especially those who have just started hemodialysis treatment.
Patients with end-stage renal disease have elevated levels of cardiac biomarkers, despite no apparent signs of cardiac dysfunction or radial damage; this is related to chronic kidney disease comorbidities and reduced renal clearance per se.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 4 and 18 years.
- •Children with chronic kidney disease (CKD) receiving regular hemodialysis for ≥1 year.
排除标准
- •Presence of structural or congenital heart disease.
- •Patients with poor echocardiographic window or arrhythmias interfering with image acquisition.
结局指标
主要结局
Left ventricular systolic function
时间窗: At baseline
Left ventricular systolic function was evaluated by calculating the left ventricular ejection fraction (LVEF) using the biplane Simpson's method from apical four- and two-chamber views.
次要结局
未报告次要终点
研究者
Mahmoud Ahmed Abdelraheem Elsayed
Lecturer of Paediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Al-Azhar University