Amino acid bioavailability of different proteins

Completed

Conditions: biobeschikbaarheid
Bioavailability study

Registration Number: NL-OMON42394

Lead Sponsor: utricia Research B.V.

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 14

Inclusion Criteria

1. Age 65 years or older
2. BMI from 20 through 30 kg/m2
3. Willingness and ability to comply with the protocol
4. Written informed consent
5. Be judged by the investigator to be in good health.

Exclusion Criteria

1. Any gastrointestinal (GI) disease or surgery that interferes with GI function
2. Known renal or hepatic failure
3. Known or suspected Diabetes Mellitus (fasting glucose level >= 7.0 mmol/L)
4. (History of) any cancer with the exception of basal cell carcinoma
5. Fever in the last 7 days prior to Visit 1
6. Haemoglobin in men <7.5 mmol/L and in women <7.0 mmol/L
7. Use of antibiotics, or anticonvulsants, or prokinetics, or antacids or any medication influencing gastric acid production, or oral and systemic use of anticoagulants, or corticosteroids, or laxatives, or growth hormone, or testosterone, or immunosuppressants or insulin within 3 weeks of Visit 1

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome parameter in this study is the time to reach half<br /><br>incremental area under the curve (t* iAUC) for the sum of all amino acids<br /><br>(total AA).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary outcome parameters of this study are:<br /><br>• The (incremental) maximum amino acid concentration ((i)Cmax), (incremental)<br /><br>area under the concentration curve ((i)AUC) and t* iAUC<br /><br>• Gastric emptying half time (t1/2), Cmax, and time until Cmax is reached<br /><br>(Tmax) and AUC<br /><br>• Satiety questionnaire </p><br>