Role of Preoperative Serum Thyroglobulin Level to Differentiate Between Different Thyroid Nodules

Not Applicable

Not yet recruiting

• Conditions: Level of Thyrogobulin in Different Thyroid Nodules
• Interventions: Procedure: Thyriodectomy

• Registration Number: NCT06157632
• Lead Sponsor: Assiut University

Brief Summary

Role of preoperative serum thyroglobulin level to differentiate between different thyroid nodules

Detailed Description

Incidence of thyroid nodules varies according to the methods of diagnosis, 4-7% by palpation and 17-67% by high resolution ultrasound.

The gold standard of diagnosis for thyroid nodules is fine needle aspiration (FNA); however, fine needle aspiration cytology (FNAC) alone is insufficient to detect cancer because of inadequate cytology (5-15%) and in cases of follicular neoplasm (15-25%) where only surgery is diagnostically conclusive. Therefore, other factors in addition to FNA should be considered to predict malignancy. This study is done to evaluate the association between elevated pre-operative thyroglobulin levels and histopathologically proven thyroid carcinoma.

Metabolism of thyroglobulin occurs in the liver and via thyroid gland and recycling of the protein takes place. Circulating thyroglobulin features a half lifetime of 65 hours. Following thyroidectomy, it will take many weeks before thyroglobulin levels become undetectable. After thyroglobulin levels become undetectable (following thyroidectomy), levels are often serially monitored.

A subsequent elevation of the thyroglobulin level is an indicator of recurrence of papillary or follicular thyroid carcinoma. Hence, thyroglobulin levels in the blood are mainly used as a tumor marker for certain kinds of thyroid cancer (particularly papillary or follicular thyroid cancer). Thyroglobulin is not produced by medullary or anaplastic carcinoma.

Therefore, this study tries to evaluate the association between the preoperative thyroglobulin levels and thyroid carcinoma proven by post-operative histopathology.

Study Timeline

• Study First Submitted: 2023-11-15
• Status Verified: 2023-12
• Study First Submitted QC: 2023-12-04
• Last Update Submitted: 2023-12-04
• Study First Posted: 2023-12-06
• Last Update Posted: 2023-12-06
• Study Start: 2023-12-20
• Primary Completion: 2024-11-18
• Study Completion: 2024-11-25

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1. age between 15 to 70 years old
2. patients with solitary thyroid nodules
3. pateints who are fit for surgeries

Exclusion Criteria

• 1_patients who are unfit for surgeries

  2_ age below 15 years and above 70 years old

  3-patients with thyroid nodule receiving drugs that affect thyroglobulin level as iodine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Patients with thyoid nodules	Thyriodectomy	Patients with thyroid nodules that will do thyroidectomy

Primary Outcome Measures

Name	Time	Method
Role of preoperative serum thyroglobulin level to differentiate between different thyroid nodules	Two year	Use of serum thyroglobulin to differentiate between different thyroid nodules preoperoperatively