HAPRPforKneeOA

Phase 2

Recruiting

• Conditions: Knee osteoarthritis; knee osteoarthritis, platelet rich plasma, hyaluronic acid

• Registration Number: JPRN-jRCTb020200036
• Lead Sponsor: Iio Kohei

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-12-25
• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

1) Prior written informed consent was obtained
2) Diagnosed with knee osteoarthritis
3) Age from 20 to 80
4) Kellgren-Lawrence grade 2 or 3
5) Possible to take MRI for exclusion of other diseases before treatment.
6) Need unilateral knee treatment with visual analog scale (VAS) pain on severe knee more than 40 and that of the other less than 40
7) Possible to visit hospital at all observational points ( considering Covid-19 pandemic, follow-up visit is substitutable for telephone consultiing )
8) Good general condition

Exclusion Criteria

1) Coagulopathy (Platlet 150,000/micro litter)
2) Anemia (Hb less than 9.0g/dl)
3) Systemic infection
4) Intake of anti-coagulant or anti-platelet drugs
5) Intake of non-steroidal anti-inflammatory drugs within 2 weeks
6) Taking hyaluronic acid injection into the target knee within 1 month
7) Steroid treatment regardless of root of administration within 3 months
8) PRP injection into the target knee within 1 year
9) Past history of knee surgery within 1 year
10) Those who are judged to be inappropreate by doctors who perform the regenerative medicine for any reason

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient based outcome KOOS: Knee injury and Osteoarthritis Outcome score

Secondary Outcome Measures

Name	Time	Method
existence of hydrarthrosis, Knee pain VAS, EQ-5D, hydrarthrosis and inflammatory findings, proteome analysis and inflammatory cytokine of joint fluid collected before injection, Complete blood count and proteome analysis of surplus PRP.