Comparing three management methods for knee osteoarthritis

Not Applicable

Completed

• Conditions: Chronic knee pain associated with imaging findings of mild to moderate degenerative changes in the knee joint; Musculoskeletal Diseases

• Registration Number: ISRCTN72048925
• Lead Sponsor: Dubai Health Authority

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-12-30
• Study Start: 2019-04-22
• Last Update Posted: 6 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. History of chronic (at least 4 months) pain or swelling of the knee
2. Imaging findings (radiography) of mild to moderate degenerative changes in the knee joint on Kellgren–Lawrence scale from I–III

Exclusion Criteria

1. Age >80 years
2. Rheumatic pathologies (rheumatoid, psoriatic and reactive arthritis, and seronegative spondyloarthritis)
3. Hematological diseases (coagulopathies)
4. Severe systemic diseases (renal, hepatic, cardiac, infections, endocrinopathies, malignancies)
5. Patients on therapy with anticoagulants–anti-aggregants
6. Use of NSAIDs within 5 days before blood procedure
7. Grade IV gonarthrosis
8. History of knee operarion, or recent knee trauma
9. Previous intra-articular injection with steroids, HA and/or PRP
10. Hb values<11 g/dl, and/or platelet values<150.000/mm3

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain severity measured using Visual Analogue Scale (VAS) of shoulder pain initially, then after 2 and 6 months of therapy. Patients point to their amount of pain on a scale of zero (no pain) to 100 (agonizing severe pain), according to their subjective feelings on a 100-millimeter scale drawn on paper. In this scale, a higher score indicates much pain.