NL-OMON30943尚未招募不适用
German Trial of Acyclovir and Corticosteroids in Herpes-simplex-virus-encephalitis (HSVE); a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial. - GACHE trial
niversiteit van Heidelberg, afdeling Neurologie0 个研究点目标入组 40 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Patients with proven HSVE (positive HSV-DNA-PCR); age 18-85 years; focal neurological signs not longer than 5 days prior to admission; informed consent; woman of childbearing potential: negative pregnancy testing in urine.
排除标准
- •History of hypersensitivity to corticosteroids; systemic corticosteroid treatment within the last 6 months or at present time; two fixed dilated pupils; pre-event score mRS>2; pregnancy; breast feeding woman; recent history of active tuberculosis or systemic fungal infection; recent head trauma/neurosurgery/peptic ulcer disease; life expectancy < 3 years; participation in another clinical trial; acute viral infections other than HSVE.
研究者
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GACHE: German trial of Acyclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis. A multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial. - GACHEHerpes simplex virus type-1 (HSV-1) is the most frequent cause of fatal sporadic encephalitis in humans. Herpes simplex encephalitis (HSE) was one of the first viral infections to be successfully treated with antiviral drugs. Mortality has been significantly reduced since the introduction of acyclovir, a specific inhibitor of HSV replication. Despite appropriate and promptly initiated antiviral therapy the incidence of persistent neurological deficits remain unacceptably high.EUCTR2005-003201-81-DEniversitätsklinikum Heidelberg450
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