NL-OMON30943Not yet recruitingNot Applicable
German Trial of Acyclovir and Corticosteroids in Herpes-simplex-virus-encephalitis (HSVE); a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial. - GACHE trial
niversiteit van Heidelberg, afdeling Neurologie0 sites40 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 40
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •Patients with proven HSVE (positive HSV-DNA-PCR); age 18-85 years; focal neurological signs not longer than 5 days prior to admission; informed consent; woman of childbearing potential: negative pregnancy testing in urine.
Exclusion Criteria
- •History of hypersensitivity to corticosteroids; systemic corticosteroid treatment within the last 6 months or at present time; two fixed dilated pupils; pre-event score mRS>2; pregnancy; breast feeding woman; recent history of active tuberculosis or systemic fungal infection; recent head trauma/neurosurgery/peptic ulcer disease; life expectancy < 3 years; participation in another clinical trial; acute viral infections other than HSVE.
Investigators
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