JPRN-jRCTs031180311已完成未知
Effect of Once Weekly Teriparatide for Bisphosphonate-Resistance Glucocorticoid Induced Osteoporosis - TeriGo Study
anki Toshihiro0 个研究点目标入组 44 人开始时间: 2019年3月15日最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 44
研究概览
简要总结
As primary outcomes, changes in lumbar and femur BMD for 72 weeks did not show significant difference between bisphosphonates and teriparatide with PPS. In ITT analysis, teriparatide treatment group showed significant increase in lumbar (especially in L1 and L2) BMD compared to bisphosphonates treatment group. Even though with the small sample size, switching to teriparatide showed the tendency to improve BMD compared with continuing bisphosphonates.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 ot applicable（—）
- 性别
- All
入选标准
- •1) Age at 20 yaers old or more.
- •Paitnets who recieve glucocorticoid (PSL 5mg or more) and bisphosphonate more than 6 months.
- •2) BMD of lumber spine (L1-4) or hip (neck or total) by DEXA is T-score of -2.0 or less, or T-score of -1.0 or less who have a history of fragility fracture.
- •3) Written informed consent required.
排除标准
- •1) Patients whose BMD of 3 or more of lumbar spines cannot be analysed because of fracture or artificial materials.
- •2) Contraindication for bisphosphonate or teriparatide.
- •3) Patients who have received teriparatide or denosumab.
- •4) Patients with active infection or malignancy.
- •5) Age less than 20 years old.
- •6) Patients who is currently pregnant, breastfeeding or willing to get pregnant.
- •7) Patients who do not give consent to the study.
- •8) Patients who are judged to be inappropriate by the physician.
研究者
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