The impact of a very-low-carbohydrate Diet on human T-cell immunometabolism

Not Applicable

Recruiting

• Conditions: ketogenic diet, low-carb, immunonutrition, chronic inflammation, low-grade inflammation, longCOVID, autoimmunity

• Registration Number: DRKS00027992
• Lead Sponsor: MU Klinikum München. Klinik für Anästhesiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-02-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

written informed consent
- age > 18 years

Cohort 2 (additionally):
- PCR-confirmed SARS-CoV-2 in the past (recovered)
- Presence of one or more symptoms from the symptom complex of the Long-COVID syndrome

Cohort 3 (additionally):
- Presentation of one or more symptoms clinically considered to be associated with chronic inflammation and increased basal inflammatory T-cell function

Cohort 4 according to Cohort 1

Exclusion Criteria

-Women who are pregnant or nursing
-Application of glucocorticoids within the last 7 days
-Serious metabolic or autoimmune disorders (such as diabetes)
-Personal relationship with examiner.

Cohort 3:
-Women who are pregnant or nursing
-Serious metabolic or autoimmune disorders (such as diabetes)
-Personal relationship with examiner.

Cohort 4:
-Women who are pregnant or nursing
-Application of glucocorticoids within the last 7 days
-Personal relationship with examiner.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes of gene expression of pro-inflammatory cytokine IFNy in CD8+ T cells after three week KD.