Efficacy of Retinal Nerve Fiber Layer (RNFL) / Retinal Thickness Ratio by Cirrus OCT Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma

• Conditions: Glaucoma; Myopia

• Registration Number: NCT00772993
• Lead Sponsor: Yonsei University

Brief Summary

Glaucoma is presumed to be an axonal disease which starts at the lamina cribrosa. This assumption has led to the monitoring of the retinal nerve fiber layer thickness for the diagnosis and monitoring of progression of glaucoma. However, varying disc size, myopia and tilted discs affect the thickness of the retinal nerve fiber layer. This study aims to ascertain the ration of the retinal nerve fiber layer against full retina as a predictor of glaucoma diagnosis and progression.

Detailed Description

Not available

Study Timeline

• Status Verified: 2008-10
• Study Start: 2008-10
• Study First Submitted: 2008-10-15
• Study First Submitted QC: 2008-10-15
• Last Update Submitted: 2008-10-15
• Study First Posted: 2008-10-16
• Last Update Posted: 2008-10-16
• Primary Completion: 2008-12
• Study Completion: 2008-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• Primary open angle glaucoma
• Myopia
• Myopia with evidence of glaucoma
• Normal controls

Exclusion Criteria

• Evidence of retinal disease
• BCVA < 0.4
• Secondary glaucoma due to intraocular inflammation
• Lens induced glaucoma
• Tumor induced glaucoma
• Neovascular glaucoma

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ratio of RNFL / Full thickness retina	2 months

Trial Locations

Locations (1)

Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University School of Medicine; 🇰🇷 Seoul, Korea, Republic of