Correlation in Retinal Nerve Fiber Layer Thickness in Uveitis and Healthy Eyes Using Scanning Laser Polarimetry and Optical Coherence Tomography
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Uveitis
- Sponsor
- Hospices Civils de Lyon
- Enrollment
- 54
- Locations
- 1
- Primary Endpoint
- Retinal nerve fiber thickness (RNFL)
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim of this study is to evaluate the correlation of retinal nerve fiber layer (RNFL) thickness measured using spectral domain optical coherence tomography (SD-OCT) and scanning laser polarimetry (SLP) in uveitic eyes compared to healthy eyes.
A descriptive, observational, prospective, consecutive, cross-sectional, controlled, mono-center case series was conducted from May to October 2015. Clinical characteristics, best-corrected visual acuity, intra-ocular pressure, RNFL thickness measurement with SD-OCT and SLP using GDx variable corneal compensation (GDx VCC) were performed for each patient. An evaluation of anterior chamber inflammation with laser flare cell meter was also carried out. Correlations between SD-OCT and GDx VCC RNFL measurement were evaluated by linear regression analysis.
Investigators
Eligibility Criteria
Inclusion Criteria
- •age ≥18 years,
- •best-corrected visual acuity better than or equal to 20/40,
- •spherical refraction between -6.00 and +3.00 diopters,
- •no retinal disease or non-glaucomatous neuropathy, and no ophthalmic surgery in the past 6 months.
Exclusion Criteria
- •Healthy eye were excluded in case of consecutive and reliable abnormal standard automated perimetry with abnormal Glaucoma Hemifield Test and pattern standard deviation outside 95% of normal limits, and optic nerve damage (asymmetric cup-to-disc ratio ≥ 0.2, rim thinning, notching, excavation, or retinal nerve fiber layer defect).
- •any history of ophthalmic disease.
Outcomes
Primary Outcomes
Retinal nerve fiber thickness (RNFL)
Time Frame: at inclusion
measures are made with scanning laser polarimetry (SLP) in micrometer