Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Retinal Nerve Fiber Layer Thickness in intermediate uveitis
研究概览
简要总结
This study investigates the variations in the retinal nerve fiber layer (RNFL) thickness during uncomplicated anterior and intermediate uveitis, respectively. The objectives are to 1 ) confirm the RNFL thickening during an uncomplicated anterior uveitis as described in the literature, 2) measure the RNFL thickness during an uncomplicated intermediate uveitis specifically and 3) describe the variation in time of RNFL thickness during the two types of uveitis.
详细描述
Thirty six individuals (18 with anterior uveitis and 18 with intermediate uveitis) will be recruited at the Centre universitaire d'ophtalmologie du CHU de Québec. RNFL thickness will be measured with optical coherence tomography at 3 times. For anterior uveitis, the RNFL thickness will be measured at presentation, 1 week and 4 to 6 weeks. For intermediate uveitis, the RNFL thickness will be measured at presentation, 4 to 6 weeks and 4 months. The initial thickness will be studied for each type of uveitis and progression over time will be studied also for each type of uveitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years old or more
- •anterior uncomplicated uveitis or intermediate uncomplicated uveitis
排除标准
- •history of uveitis in the past, other than the actual uveitis
- •history of ophthalmologic pathology with potential impact on retinal nerve fiber layer thickness
- •optic nerve or macular clinically apparent edema
- •history of glaucoma or other optic neuropathy
- •suspected or confirmed multiple sclerosis
- •ocular hypertension (intraocular pressure more than 22 mmHg)
- •reduced optical coherence tomography signal (lower than 7) on the Cirrus HD-OCT
结局指标
主要结局
Retinal Nerve Fiber Layer Thickness in intermediate uveitis
时间窗: At time 0
Change from Baseline Retinal Nerve Fiber Layer Thickness in anterior uveitis
时间窗: at 4 to 6 weeks
Change from Baseline Retinal Nerve Fiber Layer Thickness in intermediate uveitis
时间窗: at 4 months
Retinal Nerve Fiber Layer Thickness in anterior uveitis
时间窗: At time 0
次要结局
未报告次要终点