Effect of Body Position on Hemodynamics in Patients With Acute Ischemic Stroke Undergoing Ultra-early Reperfusion Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Ischemic Stroke
- Sponsor
- Yi Yang
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Differences in blood pressure variability（BPV）between different positions
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The aim of this study was to determine the differences in hemodynamics between different positions in patients undergoing ultra-early reperfusion therapy.
Detailed Description
Hemodynamic stability can prevent hypoperfusion or hyperperfusion after reperfusion therapy. It has been reported in a large number of literatures that body position has an effect on hemodynamics, but the effect of different body positions on the hemodynamics of patients undergoing ultra-early reperfusion therapy is not clear. In this study, we hypothesized that the hemodynamics of patients undergoing ultra-early reperfusion therapy would differ between different positions.
Investigators
Yi Yang
Associated Dean of The First Hospital of Jilin University
The First Hospital of Jilin University
Eligibility Criteria
Inclusion Criteria
- •Age≥18 years, \< 80 years, regardless of sex；
- •Patients with clinically confirmed acute ischemic stroke who received intravenous thrombolysis or emergency endovascular treatment;
- •Baseline National Institute of Health stroke scale（NIHSS）score ≤25;
- •Baseline Glasgow Coma Scale (GCS) ≥8;
- •Signed and dated informed consent is obtained
Exclusion Criteria
- •The patient has clear indications or contraindications, such as active vomiting, spinal cord injury；
- •Clinicians considered that the assigned body position could not be maintained; Patients unable to cooperate with all noninvasive beat-by-beat continuous BP monitoring;
- •Poor temporal window penetration;
- •Patients with diseases that seriously affect hemodynamics, such as atrial fibrillation, anemia, and hyperthyroidism;
- •Previous history of atrial fibrillation or ECG showing atrial fibrillation or arrhythmia;
- •Pregnant or lactating women;
- •Poor treatment compliance;
- •Complicated with severe systemic diseases, such as heart failure, respiratory failure, renal failure, gastrointestinal bleeding, coagulopathy, malignant tumors.
Outcomes
Primary Outcomes
Differences in blood pressure variability（BPV）between different positions
Time Frame: 0-7 days
BPV is defined as blood pressure oscillations in relation to the mean values.
Differences in heart rate variability (HRV) between different positions
Time Frame: 0-7 days
HRV is defined as heart rate oscillations in relation to the mean values.
Secondary Outcomes
- The difference of middle cerebral artery blood flow velocity between different positions.(0-7 days)