Examining the Association Between Pre-existing Sleep Disturbance and Postoperative Delirium
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Delirium
- Sponsor
- Massachusetts General Hospital
- Enrollment
- 38
- Locations
- 1
- Primary Endpoint
- Association Between Sleep and POD
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The investigators are performing this research study to understand the role of sleep disturbance on the incidence/severity of delirium after surgery. The investigators will study the brain using a polysomnography device (PSG), which records the brain's electrical activity during sleep.
Detailed Description
During this study, PSG recordings will be collected and a sleep questionnaire will be administered to participants on the night before surgery in order to establish level of preexisting sleep disturbance. Delirium assessments will be conducted during the postoperative period. On postoperative days 0 and 1, blood will be collected for analysis. Further cognitive, quality of life and pain questionnaires will be administered perioperatively.
Investigators
Oluwaseun Johnson-Akeju, MD, MMSc
Associate Professor of Anaesthesia
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •Over 60 years of age
- •Inpatient and scheduled for surgical procedure at MGH
Exclusion Criteria
- •Blindness, deafness or the inability to speak English
- •Inability to provide informed consent
- •Objective Drop Criteria
- •Post-operative intubation greater than 24 hours
Outcomes
Primary Outcomes
Association Between Sleep and POD
Time Frame: Night before surgery, approximately 13 hours
Duration of sleep in delirious vs non-delirious patients
Secondary Outcomes
- Burst Suppression Ratio(Length of surgery (2-12 hours))