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Clinical Trials/NCT03050489
NCT03050489CompletedNot Applicable

AMIRI-CABG: Assessment of Myocardial Ischemic-Reperfusion Injury During Off- and On- Pump CABG

St. Petersburg State Pavlov Medical University1 site in 1 country336 target enrollmentStarted: September 15, 2015Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
336
Locations
1
Primary Endpoint
Myeloperoxidase
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Assessment of myocardial ischemic-reperfusion injury during off- and on- pump CABG.

Detailed Description

Assessment of myocardial ischemic-reperfusion injury during off- and on- pump CABG is monitored by intraoperative measurement of serum level of myeloperoxidase before sternotomy and after sternal closure.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
30 Years to 80 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •ischemic heart disease

Exclusion Criteria

  • •valve disease
  • •diabetes millitus

Outcomes

Primary Outcomes

Myeloperoxidase

Time Frame: Level of serum myeloperoxidase just after sternal closure

Level of serum myeloperoxidase just after sternal closure

Secondary Outcomes

  • Cumulative Dose of Inotrope(Up to 30 days after procedure)
  • Systolic Function(Up to 14 days after surgical procedure)
  • Renal Dysfunction(Perioperative (before sternotomy and after sternal closure))
  • Length of Stay in Intensive Care Unit(During 30 days after procedure or more)
  • Diastolic Function(Up to 14 days after surgical procedure)
  • Atrial Fibrillation.(Up to 30 days after procedure)
  • Pulmonary Ventilation(During 30 days after procedure or more)
  • Low Cardiac Output Syndrome(Up to 30 days after surgical procedure)
  • Length of Stay in Hospital(During 30 days after procedure or more)
  • Days of Administration of Inotrope(During 30 days after procedure or more)
  • Number of Participants With Reoperation(Up to 30 days after procedure)

Investigators

Sponsor
St. Petersburg State Pavlov Medical University
Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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