Medical Records Investigation of Whether Perioperative Dexmedetomidine Will Reduce the Duration of Mechanical Ventilation or Hospital Length of Stay in Patients Undergoing Minimally Invasive Cardiac Surgery

Completed

• Conditions: Mechanical Ventilation; Hospital Length of Stay; Minimally Invasive Cardiac Surgery
• Interventions: Drug: Dexmedetomidine

• Registration Number: NCT05038111
• Lead Sponsor: Far Eastern Memorial Hospital

Brief Summary

The concept of enhanced recovery after surgery (ERAS) is utilizing in multiple specialties widely. Early tracheal extubation is one of the components of ERAS that enhances postoperative recovery and reduces the length of stay in intensive care unit (ICU).Dexmedetomidine is a highly selective, shorter-acting α2-adrenergic receptor agonist that has both analgesic and sedativeeffects.It was associated with decreased mortality, time to extubation, and hospital length of stay in cardiac surgical patients according to previous studies.The purpose of this study was to investigate the effect of perioperative dexmedetomidine on patients undergoing minimally invasive cardiac surgery(MICS) who were early extubated after surgery.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-03
• Study Start: 2021-03-11
• Primary Completion: 2021-03-22
• Study Completion: 2021-03-25
• Study First Submitted: 2021-08-26
• Study First Submitted QC: 2021-09-02
• Last Update Submitted: 2021-09-02
• Study First Posted: 2021-09-08
• Last Update Posted: 2021-09-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 81

Inclusion Criteria

• Patients undergone minimal invasive off-pump coronary artery bypass graft (CABG), valvular surgery or combined procedures at Far Eastern Memorial Hospital, New Taipei City, Taiwan between January 1, 2020 and August 31, 2020.
• Age above 20 y/o

Exclusion Criteria

• Emergency surgery
• Postoperative mechanical ventilation more than 6 hours
• Extubated in the operating room

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Dex	Dexmedetomidine	Dexmedetomidine infusion during the perioperative period

Primary Outcome Measures

Name	Time	Method
ICU and hospital length of stay	through admission, up to 1 month
postoperative mechanical ventilation duration	up to 1 week	from the time the patient arrived at the ICU until extubation

Secondary Outcome Measures

Name	Time	Method
postoperative complications	according to ICD 10 on medical record, daily to discharge, up to 1 month	atrial fibrillation, bradyarrhythmia, myocardial infarction, cerebrovascular accident, acute renal failure and delirium

Trial Locations

Locations (1)

Far Eastern Memorial Hospital; 🇨🇳 New Taipei City, Taiwan