ong-term results after surgical repair of atrioventricular septal defect

Completed

• Conditions: Q21.2; Atrioventricular septal defect

• Registration Number: DRKS00014917
• Lead Sponsor: DHZB

Brief Summary

In-hospital mortality decreased from 10.2% (n = 26) in early surgical era to 1.6% (n = 4) in late surgical era (P < 0.001). Seventy-seven patients required reoperation. Freedom from reoperation was 84.4% after 25 years. The main indication for reoperation was left atrioventricular valve regurgitation (13.8%). The multivariable Cox regression analysis revealed reoperation of the left AV valve, early surgical era, patient age <3.0 months and complex AVSD to be independent risk factors for mortality. Age <3.0 months, complex AVSD and moderate/severe left AV valve regurgitation at discharge predicted reoperation.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-07-09
• Results First Posted: 2019-05-01
• Study Completion: 2020-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 508

Inclusion Criteria

Patients who received surgical repair of atrioventricular septal defect at DHZB between 1988 and 2017.

Exclusion Criteria

Patients who did not receive surgical repair of atrioventricular septal defect at DHZB.

Study & Design

• Study Type: observational
• Study Design: Not specified