The Relationship Between Epicardial Fat Tissue and Cardiac Function in HFpEF
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure With Preserved Ejection Fraction
- Sponsor
- Dongying Zhang
- Enrollment
- 1083
- Locations
- 1
- Primary Endpoint
- Epicardial Fat Tissue
- Status
- Completed
- Last Updated
- 3 months ago
Overview
Brief Summary
Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF>50%), and ventricular muscle diastolic dysfunction and A clinical syndrome characterized by decreased compliance and increased stiffness. The pathogenesis of HFpEF is related to impaired lipid metabolism and inflammation. Epicardial adipose tissue (Epicardial Adipose tissue, EAT) is a kind of visceral adipose tissue. Related studies have shown that extracardiac Membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.However, there is still no research investigating the the relationship between epicardial fat thickness and Cardiac Function in HFpEF patients.
Detailed Description
Heart failure with preserved ejection fraction (HFpEF) refers to a group of symptoms and signs of heart failure, normal or near-normal left ventricular systolic function (EF\>50%), and ventricular muscle diastolic dysfunction and A clinical syndrome characterized by decreased compliance and increased stiffness. The pathogenesis of HFpEF is related to impaired lipid metabolism and inflammation. Epicardial adipose tissue (Epicardial Adipose tissue, EAT) is a kind of visceral adipose tissue, which is composed of adipose tissue deposited between the myocardium and the visceral layer of the pericardium. It is closely adjacent to the coronary arteries and myocardium. Related studies have shown that extracardiac Membrane fat is related to inflammation markers, cardiometabolic risk and cardiovascular disease.However, there is still no research investigating the the relationship between epicardial fat thickness and Cardiac Function in HFpEF patients. This study intends to observe the relationship between epicardial fat thickness and left and right functions in patients with HFpEF, and evaluate whether epicardial fat thickness can be used as an indicator of left and right dysfunction.
Investigators
Dongying Zhang
Dongying Zhang
Chongqing Medical University
Eligibility Criteria
Inclusion Criteria
- •Adult aged \>=18years old;
- •Diagnosed with HFpEF.
- •Diagnostic criteria including:
- •left ventricular ejection fraction ≥50%；
- •with the symptoms and/or signs of heart failure；
- •BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL；
- •at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction
Exclusion Criteria
- •LVEF less than 45% at any time;
- •Severe liver failure;
- •Primary pulmonary hypertension;
- •Age \<18 years old.
Outcomes
Primary Outcomes
Epicardial Fat Tissue
Time Frame: On admission
Epicardial Fat Tissue by cardiac color Doppler ultrasound
Cardiac Function
Time Frame: On admission
Left ventricular diastolic function and right ventricular systolic function by cardiac color Doppler ultrasound
Composite Endpoint of Worsening Heart Failure Event and Cardiovascular Death
Time Frame: From date of discharge until the date of first worsening HF event or date of death, whichever came first, assessed up to 5 years
Composite Endpoint of Worsening Heart Failure Event and Cardiovascular Death
Secondary Outcomes
- Worsening HF Event(From date of discharge until the date of first worsening HF event or date of death, whichever came first, assessed up to 5 years)
- CV Death(From date of discharge until the date of death, whichever came first, assessed up to 10 years)
- All-cause Death(From date of discharge until the date of death, whichever came first, assessed up to 10 years)