Relationship Between Adipose Tissue Distribution and Arterial Stiffness in Heart Failure With Preserved Ejection Fraction(HFpEF)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Arterial stiffness
研究概览
简要总结
Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between lipids distribution and arterial stiffness in HFpEF patients.
详细描述
Before the 21st century, Heart failure with preserved ejection fraction (HFpEF) was considered as a disease with simple diastolic dysfunction, but after the 21st century, HFpEF was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Other studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between lipids distribution and arterial stiffness in HFpEF patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult aged >=18years old;
- •Diagnosed with HFpEF.
- •Diagnostic criteria including:
- •left ventricular ejection fraction ≥50%；
- •with the symptoms and/or signs of heart failure；
- •BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL；
- •at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction
排除标准
- •LVEF less than 45% at any time;
- •Severe liver failure; 3/Other causes of shortness of breath, such as severe pulmonary disease or severe chronic obstructive pulmonary disease;
- •4.Primary pulmonary hypertension; 5.Severe valvular disease of the left heart; 6.Chronically bedridden or incapacitated; 7.Age <18 years old.
结局指标
主要结局
Arterial stiffness
时间窗: 1 day after admission
The baPWV(cm/s) of HFpEF patients
adipose tissue distribution
时间窗: 1 day after admission
The visceral fat area(cm\^2) in HFpEF patients
次要结局
未报告次要终点
研究者
Dongying Zhang
Clinical Professor
Chongqing Medical University