The Relationship Between Blood Pressure and Arterial Stiffness in HFpEF Patients With Different Levels of Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- The level of blood pressure
研究概览
简要总结
Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between blood pressure and arterial stiffness in HFpEF patients with different levels of obesity.
详细描述
Before the 21st century, Heart failure with preserved ejection fraction (HFpEF) was considered as a disease with simple diastolic dysfunction, but after the 21st century, HFpEF was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Other studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between blood pressure and arterial stiffness in HFpEF patients with different levels of obesity.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult aged >=18years old;
- •Diagnosed with HFpEF.
- •Diagnostic criteria including:
- •left ventricular ejection fraction ≥50%；
- •with the symptoms and/or signs of heart failure；
- •BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL；
- •at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction
排除标准
- •LVEF less than 45% at any time;
- •Severe liver failure;
- •Other causes of shortness of breath, such as severe pulmonary disease or severe chronic obstructive pulmonary disease;
- •Primary pulmonary hypertension;
- •Severe valvular disease of the left heart;
- •Chronically bedridden or incapacitated;
- •Age <18 years old.
结局指标
主要结局
The level of blood pressure
时间窗: On admission
The level of systolic and diastolic blood pressure of heart failure patients with preserved ejection fraction.
Arterial stiffness
时间窗: On admission
The arterial stiffness of HFpEF patients, for example brachial ankle pulse wave velocity, ardioankle vascular index and so on.
次要结局
- The change from baseline in quality of life(6 months)
- The re-hospitalization rate of heart failure(6 months)
研究者
Dongying Zhang
Clinical Professor
Chongqing Medical University