The Relationship Between Blood Pressure and Arterial Stiffness in HFpEF Patients With Different Levels of Obesity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure With Preserved Ejection Fraction
- Sponsor
- Chongqing Medical University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- The level of blood pressure
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between blood pressure and arterial stiffness in HFpEF patients with different levels of obesity.
Detailed Description
Before the 21st century, Heart failure with preserved ejection fraction (HFpEF) was considered as a disease with simple diastolic dysfunction, but after the 21st century, HFpEF was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Other studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between blood pressure and arterial stiffness in HFpEF patients with different levels of obesity.
Investigators
Dongying Zhang
Clinical Professor
Chongqing Medical University
Eligibility Criteria
Inclusion Criteria
- •Adult aged \>=18years old;
- •Diagnosed with HFpEF.
- •Diagnostic criteria including:
- •left ventricular ejection fraction ≥50%；
- •with the symptoms and/or signs of heart failure；
- •BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL；
- •at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction
Exclusion Criteria
- •LVEF less than 45% at any time;
- •Severe liver failure;
- •Other causes of shortness of breath, such as severe pulmonary disease or severe chronic obstructive pulmonary disease;
- •Primary pulmonary hypertension;
- •Severe valvular disease of the left heart;
- •Chronically bedridden or incapacitated;
- •Age \<18 years old.
Outcomes
Primary Outcomes
The level of blood pressure
Time Frame: On admission
The level of systolic and diastolic blood pressure of heart failure patients with preserved ejection fraction.
Arterial stiffness
Time Frame: On admission
The arterial stiffness of HFpEF patients, for example brachial ankle pulse wave velocity, ardioankle vascular index and so on.
Secondary Outcomes
- The change from baseline in quality of life(6 months)
- The re-hospitalization rate of heart failure(6 months)