Relationship Between Ambulatory Arterial Stiffness Index and Left Ventricular Diastolic Function in Patients With HFpEF

• Conditions: Heart Failure With Preserved Ejection Fraction

• Registration Number: NCT05059769
• Lead Sponsor: Dongying Zhang

Brief Summary

Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Ambulatory arterial stiffness index (AASI) is associated with arteriosclerosis and hypertension. There is no report on whether AASI is associated with left ventricular diastolic dysfunction in patients with HFpEF.

Detailed Description

Heart failure with preserved ejection fraction (HFpEF) is related to various complications, such as hypertension, obesity and arteriosclerosis. Ambulatory arterial stiffness index (AASI) is associated with arteriosclerosis and hypertension. AASI is especially associated with left ventricular diastolic dysfunction in patients with hypertension. Patients with HFpEF have obvious left ventricular diastolic insufficiency. However, there is still no research investigating the the relationship between AASI and left ventricular diastolic dysfunction in patients with HFpEF.

Study Timeline

• Study Start: 2020-10-10
• Study First Submitted: 2020-10-10
• Status Verified: 2021-09
• Study First Submitted QC: 2021-09-26
• Last Update Submitted: 2021-09-26
• Study First Posted: 2021-09-28
• Last Update Posted: 2021-09-28
• Primary Completion: 2021-12-31
• Study Completion: 2022-04-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Adult aged >=18years old; Diagnosed with HFpEF.

Exclusion Criteria

LVEF less than 45% at any time; Severe liver failure; Other causes of shortness of breath, such as severe pulmonary disease or severe Severe valvular disease of the left heart; Chronically bedridden or incapacitated; Age <18 years old.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Left ventricular diastolic function	1 day On admission	the ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity(E/e')

Trial Locations

Locations (1)

The first affiliated Hospital of Chongqing Medical University; 🇨🇳 Chongqing, China