A Study on the Prevention and Treatment of Mild and Moderate Alzheimer's Disease from the Perspective of Phlegm and Deficiency
- Conditions
- Alzheimer's Disease
- Registration Number
- ITMCTR2000003780
- Lead Sponsor
- Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
1. According to the diagnostic criteria of Western medicine and traditional Chinese medicine for Alzheimer's disease;
2. TCM syndrome differentiation belongs to turbid phlegm type;
3. Patients with mild to moderate Alzheimer's disease were selected by clinical dementia rating scale, Montreal cognitive assessment scale and mini mental state examination scale;
4. The age ranged from 45 to 80 years old, both male and female;
5. Patients or their family members voluntarily participated in the study with informed consent.
1. Patients with severe neurological impairment, such as hemiplegia, aphasia and visual and hearing impairment;
2. Patients with cognitive impairment caused by other system diseases, such as severe circulatory system, digestive system, urinary system, endocrine system and other diseases;
3. Patients with underlying diseases that affect the oral administration, absorption and metabolism of drugs;
4. Patients with adverse habits, such as alcoholics, drug addicts, psychotropic substance abusers and antidepressants, were included in the study;
5. Patients with serious life-threatening primary diseases and psychosis were found;
6. Allergic constitution;
7. Taking other traditional Chinese medicine or Chinese patent medicine to improve cognition;
8. Patients who participated in other clinical trials within the last 3 months.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time of taking Chinese Medicine;
- Secondary Outcome Measures
Name Time Method MoCA;MMSE;CDR;ADL;ADAS-cog;TCM Symptom Score Scale;