Comparison of the Analgesic Effect of Ketamine Versus Dexmedetomidine Added to Local Anesthetic in TAP Block for Lower Abdominal Cancer Surgery
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- postoperative rescue morphine consumption
研究概览
简要总结
Comparing the analgesic effects of ketamine and dexmedetomidine when added to local anesthetic in TAP block for postoperative analgesia after lower abdominal cancer surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients ASA I and II to whom abdominal surgery for cancer will be conducted will be included in the study
排除标准
- •Coagulopathies
- •ASA III or IV, patient refusal, sensitivity to the used drugs
研究组 & 干预措施
control group,
saline in the same volume will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
干预措施: Ketamine (Drug)
control group,
saline in the same volume will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
干预措施: dexmedetomidine (Drug)
ketamine group,
ketamine in a dose of 0.5mg/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
干预措施: dexmedetomidine (Drug)
ketamine group,
ketamine in a dose of 0.5mg/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
干预措施: control group (Drug)
dexmedetomidine group
dexmedetomidine in a dose of 1ug/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
干预措施: Ketamine (Drug)
dexmedetomidine group
dexmedetomidine in a dose of 1ug/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
干预措施: control group (Drug)
结局指标
主要结局
postoperative rescue morphine consumption
时间窗: 24 hours postoperative
postoperative rescue morphine consumption
次要结局
未报告次要终点
研究者
Ahmed H Othman
Associte professor
Assiut University