Ketamine Versus Dexmedetomidine With Local Anesthetic in TAP Block

Phase 2

Completed

• Conditions: Lower Abdominal Cancer; Postoperative Analgesia
• Interventions: Drug: Ketamine; Drug: control group; Drug: dexmedetomidine

• Registration Number: NCT03060070
• Lead Sponsor: Assiut University

Brief Summary

Comparing the analgesic effects of ketamine and dexmedetomidine when added to local anesthetic in TAP block for postoperative analgesia after lower abdominal cancer surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-02-17
• Study First Submitted QC: 2017-02-20
• Study First Posted: 2017-02-23
• Study Start: 2017-03-10
• Primary Completion: 2017-06-25
• Status Verified: 2017-07
• Study Completion: 2017-07-01
• Last Update Submitted: 2017-07-01
• Last Update Posted: 2017-07-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• All patients ASA I and II to whom abdominal surgery for cancer will be conducted will be included in the study

Exclusion Criteria

• Coagulopathies
• ASA III or IV, patient refusal, sensitivity to the used drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
dexmedetomidine group	control group	dexmedetomidine in a dose of 1ug/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
ketamine group,	control group	ketamine in a dose of 0.5mg/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
control group,	Ketamine	saline in the same volume will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
control group,	dexmedetomidine	saline in the same volume will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
ketamine group,	dexmedetomidine	ketamine in a dose of 0.5mg/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery
dexmedetomidine group	Ketamine	dexmedetomidine in a dose of 1ug/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery

Primary Outcome Measures

Name	Time	Method
postoperative rescue morphine consumption	24 hours postoperative	postoperative rescue morphine consumption

Trial Locations

Locations (1)

South Egypt Cancer Institute; 🇪🇬 Assiut, Assiut University, Egypt