The acute effects of cannabis on the brai
- Conditions
- cannabis psychosisdopamine
- Registration Number
- NL-OMON27472
- Lead Sponsor
- Maastricht University
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
1. Aged between 18 and 50
2. Life-time use of cannabis without having experienced negative effects (e.g. bad trip, toxic psychosis)
Exclusion Criteria
1. Head trauma
2. Respiratory, cardiovascular, neurological disease, severe renal or liver dysfunction
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A. Striatal dopamine response after THC and placebo, as measured with PET and [18F]fallypride <br /><br>B. Psychotic experiences after THC and placebo, as measured with i) novel computer-assisted tasks and ii)clinical interviews
- Secondary Outcome Measures
Name Time Method C. Influence of genetic variation