Cannabis as a cause of psychosis: An ecogenetic study linking cannabis-induced dopamine response to psychotic mechanisms and experiences
Completed
- Conditions
- schizophrenia and psychosis10039628
- Registration Number
- NL-OMON33989
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 45
Inclusion Criteria
18-50 years of age
life-time use of cannabis without having experienced negative effects
BMI between 18.5 and 27
diagnosis of schizophrenia according to DSM-IV (only patients)
having given informed consent (written and orally)
Exclusion Criteria
head trauma
severe renal or liver dysfunction
alcohol use in excess of 5 units per day
weekly use of illicit drugs (other than cannabis)
pregnancy
breast-feeding
personal or family history of psychosis or use of antipsychotic medication (only valid for healthy participants who are no first degree relatives of patients with schizophrenia)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>(i) Dopamine response after THC and placebo<br /><br>(ii) Psychotic experiences in response to THC and placebo as measured with i)<br /><br>computer-assisted tasks and ii) clinical interviewing</p><br>
- Secondary Outcome Measures
Name Time Method <p> (i) genotype (on the basis of DNA analyses)</p><br>