Efficacy of 1% permethrin lotion in treatment of head lice infestations in primary school children in Thailand
Phase 4
Completed
- Conditions
- Male and female schoolchildren aged 6 to 13, with head lice infestations.Pediculus humanus capitis, head lice infestations, kdr mutation, permethrin lotion
- Registration Number
- TCTR20240715005
- Lead Sponsor
- Fundamental Fund, Thailand Science Research and Innovation (TSRI)
- Brief Summary
Permethrin cure rates were approximately 50%, and the prevalence of infestation was 6.1%. The frequency of kdr mutations was 63.2%. A substantial association between the clinical response and the kdr genotype was revealed by multivariate regression analysis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 71
Inclusion Criteria
Male and female schoolchildren aged 6 to 13, with at least one live head louse identified through the dry combing method.
Exclusion Criteria
Patients with a history of allergy to permethrins, pyrethroids, pyrethrins, or chrysanthemum, coexisting scalp diseases and disorders, use of any pediculicide-based products or medication within the last two weeks, non-adherence to the protocol, or refusal to complete informed consent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Free from head lice (cure) 7 and 14 days after first treatment no living lice,kdr mutation before treatment PCR-RFLP
- Secondary Outcome Measures
Name Time Method Adverse events 7 and 14 days after first treatment pruritus and burning score