Achieving Better Clinical Outcomes With Blastocyt Transfer in Poor Responders: a Prospective Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Live birth rate
研究概览
简要总结
A Prospective cohort study including couples with poor responder females who undergoing ICSI
详细描述
Purpose:
To determine the optimal embryonic stage for transfer in poor responders.
Method:
Patients were divided into day 3 transfer group and day 5 transfer group. All cases had the same stimulation protocol and planning to do fresh embryo transfer. Assessments will be at Day 1, Day 3 and Day 5/6 according to Gardner's criteria 1999. Embryological and clinical data were recorded and then analyzed using SPSS (version 23) statistical software.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •poor responders females with AMH≤ 1.2ng and have ≤ 5 mature oocytes
- •couples whose planning to do fresh transfer
- •male partners have normal semen parameters according to WHO 2010.
排除标准
- •sperm or oocyte donation
- •gestational carriers
结局指标
主要结局
Live birth rate
时间窗: delivery of healthy neonate after 37 weeks of pregnancy
percentage of cycles started with the intent of egg retrieval that led to a live birth.
Implantation rate
时间窗: 6 weeks of pregnancy
Percentage of the implanted embryos number for each group / number of transferred embryos.
次要结局
- Clinical pregnancy rate(after 6 weeks of embryonic transfer)
- Cancellation rate(5:6 days of ICSI)
- High quality day 3 embryos(72 hours after ICSI)
- Blast rate(5:6 days of ICSI)
- Fertilization rate(16:19 hours after intracytoplasmic injection(ICSI))
- Cleavage rate(72 hours after ICSI)
- High quality blast rate(5:6 days of ICSI)