Pilot Study: Is Overactive Bladder Caused by Subacute Urinary Tract Infections?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Number of Subjects With Evidence of Bacteria in Urine Sample by Microbiologic Evaluation
研究概览
简要总结
The purpose of this study is to look for evidence of bacteria in the urine or bladder of people with overactive bladder. Because you do not have overactive bladder, your participation in this study will be used as a comparison to those who have overactive bladder.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Urge urinary incontinence based on clinical history and bladder diary; subjects must have 3 or more urge incontinence episodes/day and 10 or more voids/day.
- •21 years or older
- •Healthy volunteers for control subjects
排除标准
- •Active cystitis performed on a catheterized urine specimen
- •Known or suspected correctable etiology for her urge incontinence
- •History of urinary tract stones, foreign bodies or malignancy
- •History of recurrent Urinary Tract Infections
- •Pregnant women, children
- •Evidence of urge urinary incontinence or more than 1 episode of stress incontinence/day by control subject
结局指标
主要结局
Number of Subjects With Evidence of Bacteria in Urine Sample by Microbiologic Evaluation
时间窗: within one week of enrollment
Sterile specimens were obtained from subjects. The urethra was prepared with Betadine and an 8Fr urethral catheter passed into the bladder and urine obtained in a sterile container. Bladder washings were obtained after urine was completely emptied from the bladder via the catheter. Saline (60ccs) was used to vigorously irrigate the bladder 2-3 times through the 8 Fr catheter. The bladder washings were then collected and placed in a sterile container. The experimental cultures included 100ml inoculated on Blood Agar, MacConkey Agar and Brucella Blood Agar, incubated for 72 hours at 35-37 C in ambient atmosphere supplemented with 5-8% carbon dioxide. Colonies were counted to quantify the cfu/ml and all growth of any organism was reported. Organisms were then identified using standard microbiologic techniques.
次要结局
未报告次要终点