临床试验/NCT02424240

NCT02424240已完成不适用

The Emerging Role of Serum IGF-I/IGFBP-3 Ratio in the Diagnosis of Children With Growth Hormone Deficiency

University of Jordan0 个研究点目标入组 134 人开始时间: 2011年5月最近更新: 2015年4月22日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University of Jordan
入组人数: 134
主要终点: Serum IGF-1/IGFBP-3 ratio

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

A 35-month cross-sectional observational study was conducted at an outpatient university hospital in Amman, Jordan. We obtained a comprehensive medical and laboratory evaluation for 134 short-statured children (64 boys and 70 girls, aged 4-16 years). Complete and partial growth hormone deficincy (GHD) were defined as peak forwth hormone (GH) response of 5 and 7 ng/ml [IRMA/ DiaSorin®], respectively in both clonidine stimulation and insulin tolerance tests. Serum IGF-I, IGFBP-3 and IGF-I/IGFBP-3 ratio were determined for all participants.

研究设计

研究类型: Observational
时间视角: Retrospective

入排标准

年龄范围: 4 Years 至 16 Years（Child）
性别: All
接受健康志愿者: 是

入选标准

•children presented to Jordan Univeristy Hospital (JUH) outpatient endocrinology clinic for the evaluation of short stature (SS)

排除标准

•(i) their parents could not provide written consent for them; (ii) they were lost to follow up; (iii) they could not perform clonidine stimulation tests (CST) or insulin tolerance test (ITT) due to a medical contraindication (e.g. cardiac disorder, seizure disorder); (iv) they had received GH therapy in the past; (v) they were known to have pituitary diseases, hypothyroidism, hypogonadism or discovered to have panhypopituitarism or (vi) they have malnutrition, diabetes mellitus, liver disease, or other chronic illnesses.

结局指标

主要结局

Serum IGF-1/IGFBP-3 ratio

时间窗: 33 months

次要结局

未报告次要终点

研究者

发起方

University of Jordan

申办方类型

Other

责任方

Principal Investigator

主要研究者

Ayman Zayed, M.D., MSc, FACE, FACP

Ayman Zayed

University of Jordan

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