A Study to Compare Genetic Variations of IGF-I and IGF-II
- Conditions
- Dementia
- Registration Number
- NCT01329523
- Lead Sponsor
- Avera McKennan Hospital & University Health Center
- Brief Summary
The purpose of this study is to determine if insulin-like growth factors (IGF) play a role in the development of dementia, specifically Alzheimer's disease (AD). The study will compare results from genetic testing between patients with AD and two other groups: younger biological family members of the AD patients and individuals without AD matched by age to the AD patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
- Men and women between the ages of 50 and 81 years old who have a diagnosis of dementia
- Men and women who are at least 18 years old and are biologically related to the study subject with dementia
- Control subjects must not have a diagnosis of dementia and must be matched in age to the study subjects with dementia
- Biological family members of the dementia patient who are either younger than 17 years of age or older than the patient with dementia
- Biological family members with a diagnosis of dementia
- Age-matched control subjects with a diagnosis of dementia
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Genetic polymorphisms of insulin-like growth factors Single clinic visit (day 1) This study consists of a single clinic visit. After subject has completed the informed consent process and meets eligibility criteria, a blood sample and a saliva sample will be collected. Genetic results from this one-time specimen collection will be evaluated and compared with results from participants in the other two study groups. Outcomes will be measured comparatively.
- Secondary Outcome Measures
Name Time Method Genetic testing of Apolipoprotein (APO) E4 Single clinic visit (day 1) This study consists of a single clinic visit. After subject has completed the informed consent process and meets eligibility criteria, a blood sample and a saliva sample will be collected. Genetic results from this one-time specimen collection will be evaluated and compared with results from participants in the other two study groups. Outcomes will be measured comparatively.
Related Research Topics
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Trial Locations
- Locations (1)
Avera Research Institute
🇺🇸Sioux Falls, South Dakota, United States
Avera Research Institute🇺🇸Sioux Falls, South Dakota, United States