Mapping and ablation of the functional substrate in ischemic heart disease with mini- micro- and conventional electrodes
- Conditions
- Heart rhythm disorderVentricular arrhythmia10007521
- Registration Number
- NL-OMON50104
- Lead Sponsor
- Cardiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 35
- Sustained within 6 months before enrolment.
- Accepted for catheter ablation of VT.
- Prior MI. The diagnosis of MI will be based on the presence of wall motion
abnormalities, non-reversible perfusion defects and/or subendocardial or
transmural late gadolinium enhancement areas in the perfusion territory of a
significant stenotic coronary artery (>75 %).
- Age < 18 years
- Inadequate patient competence
- Pregnancy
- Presence of any of the following conditions:
o Non-ischemic left-dominant cardiomyopathy
o Right dominant cardiomyopathy
o Hypertrophic cardiomyopathy
o LV non-compaction cardiomyopathy
o Restrictive cardiomyopathy
o (Sub)acute myocarditis
o Cardiac sarcoidosis
o Chagas disease
o Tachycardia-induced cardiomyopathy
o Primary significant valve disease
o Congenital heart disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Mapping accuracy of the micro-electrodes of the QDOT catheter in re-<br /><br>identifying evoked delayed potentials (EDP) detected by the Pentaray catheter<br /><br>and confirmation of EDP elimination.</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Mapping time using the QDOT catheter to delineate EDP compared to functional<br /><br>substrate delineation with the Pentaray catheter<br /><br>- Wave-front and pacing-rate (coupling interval) dependency of QDOT micro/conv.<br /><br>vs. Pentaray for voltage mapping (=scar delineation) and functional substrate<br /><br>mapping (=EDP identification)<br /><br>- VT recurrence<br /><br>- All course mortality</p><br>