Tavistock Adult Depression Study: Comparing the effectiveness of usual GP care with once weekly psychoanalytic psychotherapy for people suffering from chronic, treatment-resistant depressio

Not Applicable

Completed

Conditions: Treatment-resistant depression
Mental and Behavioural Disorders
Other depressive episodes

Registration Number: ISRCTN40586372

Lead Sponsor: The Tavistock Charitable Foundation (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 129

Inclusion Criteria

1. Male and female primary care patients between 18 to 65 years of age
2. Major depressive disorder or dysthymia based on Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria and minimum symptom severity on the Beck Depression Inventory (BDI) of 21 or above and 14 or above on the Hamilton Rating Scale for Depression (HRSD)
3. Minimum of a two-year history of depression
4. Atleast two previous failed treatment attempts, one of which was with an anti-depressant
5. Able to speak conversational English and be seen at the Tavistock Clinic, London
6. Willing to enter a randomised controlled trial

Exclusion Criteria

Primary care patients with:
1. Recent (previous five years) history of psychosis
2. Recent (previous five year) history of bi-polar disorder
3. Moderate or severe learning disabilities
4. Recent history (previous two years) of psychiatric input for, or diagnosis of, substance dependency (alcohol abuse more than 21 units/week; drug abuse more than 4/week)
5. Patients currently in psychological therapy
6. Patients who have received psychoanalytic psychotherapy in the previous two years

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in depression severity as indicated by the independent, double-rated Hamilton Rating Scale of Depression (HRSD, Hamilton, 1967) at baseline, 3 months, 6 months, 9 months, 12 months, 15 months, 18 months, 6 months follow-up, 12 months follow-up and 24 months follow-up. It is a semi-structured interview consisting of 21 depression items, which yield a range of scores from 0 - 62.

Secondary Outcome Measures