Airway Response to Repeat Allergen Challenge and the Effect of Ibuprofen in Mild Atopic Asthma
- Registration Number
- NCT02327234
- Lead Sponsor
- University of Saskatchewan
- Brief Summary
The study will assess airway responses in mild atopic asthmatics undergoing repeat allergen challenge testing and will investigate whether ibuprofen changes the response.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Inclusion Criteria
- diagnosis of mild asthma, currently well controlled requiring only a bronchodilator (e.g. salbutamol) as needed and infrequently
- has allergies that trigger asthma
- responds to methacholine challenge at 16mg/ml or less
- has FEV1 > 69.5% predicted
Exclusion Criteria
- respiratory illness within 4 weeks
- other medical condition assessed by the principal investigator that would put the participant at risk or influence the integrity of the data
- pregnant or lactating females
- hypersensitivity to ibuprofen
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Ibuprofen ibuprofen 400mg (2X200mg) ibuprofen single dose once Placebo Placebo identical appearing lactose capsules single dose 2 capsules once
- Primary Outcome Measures
Name Time Method Airway response to inhaled allergen at time of allergen inhalation challenge and for 7 hours after area under forced expiratory volume in one second versus time curve; 0-3hours (early response) and 3-7 hours (late response)
- Secondary Outcome Measures
Name Time Method Airway response to inhaled methacholine day before allergen inhalation challenge and 8 hours after allergen inhalation challenge delta log methacholine PC20 (provocative concentration of methacholine causing a 20% decrease in the forced expiratory volume in one second)
Trial Locations
- Locations (1)
University of Saskatchewan
🇨🇦Saskatoon, Saskatchewan, Canada