Serum Neuroglobin and Nogo-A Concentrations in Acute Traumatic Brain Injury
- Conditions
- Traumatic Brain Injury
- Registration Number
- NCT02229643
- Lead Sponsor
- Shanghai 6th People's Hospital
- Brief Summary
Neuroglobin has been described as a marker of traumatic brain injury. Nogo-A plays an important role in mediating neuroanatomical plasticity and functional recovery following traumatic brain injury. The investigators sought to examine the changes in serum neuroglobin and Nogo-A concentrations in patients with traumatic brain injury during the initial 96-h posttraumatic period and assessed the relation of neuroglobin and Nogo-A to Glasgow Coma Score and prognosis of such patients with traumatic brain injury.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 34
- Patients who suffered head trauma and whose highest abbreviated injury score (AIS) was 3 or less (other than head injury)
- Patients who delivered to hospital within 4 h
- Patients who suffered open injuries
- Patients who had existing prior neurological disease
- Patients whose serial serum samples could not be obtained
- Patients less than 18 years of age
- Patients who suffered severe life-threatening injury to organs other than the brain
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Glasgow Outcome Scale scores 6 months Glasgow Outcome Scale 1 = death; Glasgow Outcome Scale 2 = vegetative state; Glasgow Outcome Scale 3 = severe neurological deficit; Glasgow Outcome Scale 4 = mild neurological deficit and Glasgow Outcome Scale 5 = premorbid level of functioning or completely recovery. Unfavorable outcome was defined as a Glasgow Outcome Scale score of ≤ 3, and favorable outcome was defined as a Glasgow Outcome Scale score of \> 3.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Shanghai Sixth People's Hospital
🇨🇳Shanghai, China