Neuroglobin and Nogo-A as Biomarkers for the Prognosis of Closed Traumatic Brain Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Glasgow Outcome Scale scores
研究概览
简要总结
Neuroglobin has been described as a marker of traumatic brain injury. Nogo-A plays an important role in mediating neuroanatomical plasticity and functional recovery following traumatic brain injury. The investigators sought to examine the changes in serum neuroglobin and Nogo-A concentrations in patients with traumatic brain injury during the initial 96-h posttraumatic period and assessed the relation of neuroglobin and Nogo-A to Glasgow Coma Score and prognosis of such patients with traumatic brain injury.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who suffered head trauma and whose highest abbreviated injury score (AIS) was 3 or less (other than head injury)
- •Patients who delivered to hospital within 4 h
排除标准
- •Patients who suffered open injuries
- •Patients who had existing prior neurological disease
- •Patients whose serial serum samples could not be obtained
- •Patients less than 18 years of age
- •Patients who suffered severe life-threatening injury to organs other than the brain
结局指标
主要结局
Glasgow Outcome Scale scores
时间窗: 6 months
Glasgow Outcome Scale 1 = death; Glasgow Outcome Scale 2 = vegetative state; Glasgow Outcome Scale 3 = severe neurological deficit; Glasgow Outcome Scale 4 = mild neurological deficit and Glasgow Outcome Scale 5 = premorbid level of functioning or completely recovery. Unfavorable outcome was defined as a Glasgow Outcome Scale score of ≤ 3, and favorable outcome was defined as a Glasgow Outcome Scale score of \> 3.
次要结局
未报告次要终点
研究者
Hao Chen
Doctor
Shanghai 6th People's Hospital