Changes in vascular function after a reduced sitting interventio
Recruiting
- Conditions
- sedentary behaviour, reduced sitting, vascular function, cardiovascular risk
- Registration Number
- NL-OMON27638
- Lead Sponsor
- Radboud University Medical Center Nijmegen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
People who spend >40 hours per week sitting with an increased cardiovascular risk. An increased risk for cardiovascular disease was defined as those older than 45 years (men) or 55 (women) and presence of at least 1 cardiovascular risk factor.
Exclusion Criteria
Persons who are not physically able to perform light-intensity physical activity such as standing and walking.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main parameter of this study is the change in vascular function, as is measured by superficial femoral artery FMD at baseline, before and after intervention. Improvements in vascular function are associated with reduced risk for future cardiovascular events (17). Endothelial function will be measured before and after a challenge of 3 hours continuous sitting and after a challenge of 3 hours sitting with short bouts of light intensity activity every 30 minutes. This challenge will be repeated after the intervention period to evaluate whether the effects an acute challenge of prolonged sitting is different after intervention.
- Secondary Outcome Measures
Name Time Method Cerebral autoregulation will serve as secondary outcome. Change in cerebral autoregulation and cerebrovascular reactivity will be measured after a challenge of 3 hours continuous sitting and after a challenge of 3 hours sitting with short bouts of light intensity activity every 30 minutes.<br>As an explorative aim, markers of inflammation NO synthesis, coagulation and adhesion properties, and levels of oxidative stress will be secondary parameters in all subjects. <br /><br>In addition, in all subjects physical fitness will be assessed as an explorative aim.