Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease

Not Applicable

• Conditions: Chronic Liver Disease; Hepatocellular Carcinoma

• Registration Number: NCT00629668
• Lead Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Brief Summary

The prognosis of Hepatitis B virus (HBV)infection varies from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma (HCC).Both viral and host genetic factors contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study aime to assess their effects and interaction on disease severity of HBV-related chronic liver disease and HCC.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Status Verified: 2007-07
• Study Completion: 2007-12
• Study First Submitted: 2008-02-26
• Study First Submitted QC: 2008-03-05
• Last Update Submitted: 2008-03-05
• Study First Posted: 2008-03-06
• Last Update Posted: 2008-03-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• HBV-positive patients

Exclusion Criteria

• HBV-negative patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
cytokine gene polymorphism	years

Secondary Outcome Measures

Name	Time	Method
cytokine gene polymorohism on severity of disease	years

Trial Locations

Locations (1)

Kaohsiung Medical University Chung-Ho Memorial Hospital; 🇨🇳 Kaohsiung, Taiwan