Vitamin D in Healthy Adults After Strenuous Endurance Exercise

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Vitamin D; Dietary Supplement: Medium-chain triglycerides

• Registration Number: NCT05779410
• Lead Sponsor: Taipei Medical University

Brief Summary

The purpose of this study was to investigate the effects of vitamin D supplementation on biochemical response and aerobic capacity after strenuous endurance exercise (SEE).

Detailed Description

All participants conducted a graded exercise test on an ergometric bicycle to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 65% VO2max was conducted for a SEE test by ergometric bicycle for 2 hours, followed by increasing 100 RPM until exhaustion. Venous blood samples were drawn before, immediately after, 2-hour after, 4-hour after, 8-hour after, and 24-hour after the SEE test to determine the concentrations of biomarkers. Data was analyzed by Two-way mixed design ANOVA.

Study Timeline

• Study Start: 2021-01-20
• Primary Completion: 2021-12-08
• Study Completion: 2021-12-08
• Status Verified: 2023-02
• Study First Submitted: 2023-02-20
• Study First Submitted QC: 2023-03-09
• Last Update Submitted: 2023-03-09
• Study First Posted: 2023-03-22
• Last Update Posted: 2023-03-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 35

Inclusion Criteria

• The volunteers included have conditions as stated below :

  1. no history of cardiovascular, liver, kidney and diabetes disease
  2. no acute sport injury
  3. male adult whose concentration of 25(OH)D is under 30 ng/mL, and maximal oxygen consumption is over 40 ml/kg/min
  4. did not participated in any clinical trials or research in the last 3 months before our experiment
  5. no supplements were taken during the experimental period
  6. were requested to maintain their regular daily life style and avoid alcohol intake

Exclusion Criteria

• The volunteers were excluded if they have the situation stated below:

  1. history of cardiovascular, liver, kidney and diabetes disease
  2. acute sport injury
  3. their concentration of 25(OH)D is over 30 ng/mL, or maximal oxygen consumption is under 40 ml/kg/min
  4. participated in any clinical trials or experimental research in the last 3 months before our experiment
  5. taking supplement during the experimental period
  6. did not maintain their regular eating habit or drink alcohol

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Vitamin D group	Vitamin D	-
Placebo group	Medium-chain triglycerides	-

Primary Outcome Measures

Name	Time	Method
Concentration of IL-6	24-hour after exercise
Concentration of CD8+	24-hour after exercise
Concentration of CD19+	24-hour after exercise
Concentration of CD56+	24-hour after exercise
Concentration of IgA	24-hour after exercise
Concentration of Cathelicidin	24-hour after exercise
Concentration of TNF-α	24-hour after exercise
Concentration of IL-1β	24-hour after exercise
Concentration of IFN-γ	24-hour after exercise
Concentration of eosinophil	24-hour after exercise
Concentration of basophil	24-hour after exercise
Concentration of Neutrophil	24-hour after exercise
Concentration ofNeutrophil	immediately after exercise
Concentration of monocyte	24-hour after exercise
Concentration of lymphocyte	24-hour after exercise
Concentration of CD4+	24-hour after exercise
Concentration of IL-2	24-hour after exercise
Concentration of IL-4	24-hour after exercise
Concentration of IL-8	24-hour after exercise
Concentration of IL-10	24-hour after exercise
Concentration of TBARS	24-hour after exercise
Concentration of PC	24-hour after exercise
Concentration of SOD	24-hour after exercise
Concentration of catalase	24-hour after exercise
Concentration of GPx	24-hour after exercise
Concentration of CK	24-hour after exercise
Concentration of LDH	24-hour after exercise
Concentration of CRP	24-hour after exercise

Trial Locations

Locations (1)

Taipei Medical University; 🇨🇳 Taipei, Taiwan