NCT01465542已完成不适用
Treatment of Acetaminophen Toxicity With Intravenous vs. Oral N-acetylcysteine: A Retrospective Review
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Length of NAC treatment in hours
研究概览
简要总结
Retrospective chart review of patients who receive N-acetylcysteine for Acetaminophen(APAP) toxicity to assess length of oral vs. IV treatment and the effect of a Clinical Pharmacology and Toxicology division in the management of APAP ingestions.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 1 Month 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admitted to CHMCA between June 1, 2008 to June 30, 2011
- •Qualifying ICD-9 diagnosis code for the following APAP overdose situations: poisoning, accidental, suicide attempt, therapeutic use, assault, and undetermined (965.4, E850.4, E950.0, E935.4, E962.0, E980.0)
- •Serum APAP concentration above the possible hepatotoxic line on the Rumack-Matthew's nomogram if obtained > 4 hours post ingestion
- •Between ages 0-21 years on date of admission
- •Acute APAP ingestion
排除标准
- •Serum APAP concentrations not actually documented
- •Did not receive the oral or IV NAC treatment
- •Preexisting liver disease such as cirrhosis or hepatitis C
- •Patient > 21 years of age on the date of admission
- •Chronic APAP ingestion
结局指标
主要结局
Length of NAC treatment in hours
时间窗: Retrospective data collection for patient's hospital admission, max estimated 5days
Length of NAC treatment (in hours) for both IV and PO formulations used in patients with APAP toxicity
次要结局
- Pharmacology & Toxicology consults(Retrospective data collection for length of patient's hospital admission, max estimated 5 days)
研究者
Martha Blackford, PharmD
PharmD
Akron Children's Hospital
研究点 (1)
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