NL-OMON55985
Recruiting
Not Applicable
Procalcitonin-guided treatment regarding antibiotic use for acute COPD exacerbations: a prospective randomised controlled trial - PRECISION study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COPD flare-up
- Sponsor
- Erasmus MC, Universitair Medisch Centrum Rotterdam
- Enrollment
- 693
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- COPD, according to GOLD 2018 definition
- •\- Hospitalization because of severe acute exacerbation of COPD
- •\- Post\-bronchodilator FEV1/FVC \< 0,70 and FEV1% \< 80%pred. within last 5 years
- •or a lung function within 2 months after the index admission that meets these
- •\- At least 40 years of age
- •\- Smokers or ex\-smokers with \> 10 packyears
- •\- Written informed consent
- •\- Start of symptoms no more than 7 days before admission
- •\- Presence of at least 2 major symptoms of the modified Anthonisen
- •criteria (acute deterioration
Exclusion Criteria
- •\- Indication for ICU and or non\-invasive ventilation \< 72h of admission
- •\- Pneumonia, radiologically confirmed
- •\- Infection at another site and/or sepsis according to the SIRS criteria
- •(with tachycardia and
- •tachypnea not being caused by the exacerbation).
- •\- COPD before age 40\.
- •\- Asthma, without presence of COPD.
- •o Patients with COPD , with or without a history of asthma (in
- •childhood or as an adolescent)
- •will NOT be excluded.
Outcomes
Primary Outcomes
Not specified
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