Intraocular Pressure, Blood Pressure, Ocular Perfusion and Blood Flow Fluctuations in Glaucoma Patients
- Conditions
- Open Angle Glaucoma
- Interventions
- Device: Color Doppler Imaging
- Registration Number
- NCT01304264
- Lead Sponsor
- Lithuanian University of Health Sciences
- Brief Summary
To evaluate whether add-on to prostaglandin therapy with twice a day (bid) dorzolamide is statistically superior to twice a day (bid) timolol with regard to increasing ocular blood flow
- Detailed Description
Hypotensive treatments for glaucomatous optic neuropathy (GON), depending on their chemical composition can influence the ocular circulation independent of intraocular pressure (IOP) reduction. It is therefore important not only to identify ocular blood flow deficits in GON, but also document the influence of GON treatments on the ocular circulation
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 35
- Open angle glaucoma subjects receiving prostaglandin monotherapy in both eyes
- younger than 18 years old
- women of child bearing potential
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description combination topical glaucoma treatment Color Doppler Imaging timolol or dorzolamide add on latanoprost monotherapy
- Primary Outcome Measures
Name Time Method Ocular Color Doppler Imaging 8 AM; 8 PM Color Doppler Imaging
* Nasal post ciliary artery (NPCA)
* Temporal posterior ciliary artery (TPCA)
* Ophthalmic artery (OA)
* Central retinal artery (CRA)
- Secondary Outcome Measures
Name Time Method IOP, BP, OPP (mean, fluctuations, amplitude) 8 AM-12AM-4PM-8PM IOP, BP, OPP (mean, fluctuations, amplitude) Goldmann applanation tonometry Brachial artery pressure and radial pulse
Trial Locations
- Locations (1)
Eye Clinic Lithuania Health Science Hospital Kaunas Clinics
🇱🇹Kaunas, Lithuania