Comparison of Intraocular Pressure, Blood Pressure, Ocular Perfusion and Blood Flow Fluctuations During the Addition of Dorzolamid vs Timolol in Glaucoma Subjects Treated With Prostaglandin Analogue Monotherapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Open Angle Glaucoma
- Sponsor
- Lithuanian University of Health Sciences
- Enrollment
- 35
- Locations
- 1
- Primary Endpoint
- Ocular Color Doppler Imaging
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
To evaluate whether add-on to prostaglandin therapy with twice a day (bid) dorzolamide is statistically superior to twice a day (bid) timolol with regard to increasing ocular blood flow
Detailed Description
Hypotensive treatments for glaucomatous optic neuropathy (GON), depending on their chemical composition can influence the ocular circulation independent of intraocular pressure (IOP) reduction. It is therefore important not only to identify ocular blood flow deficits in GON, but also document the influence of GON treatments on the ocular circulation
Investigators
Ingrida Januleviciene
MD
Lithuanian University of Health Sciences
Eligibility Criteria
Inclusion Criteria
- •Open angle glaucoma subjects receiving prostaglandin monotherapy in both eyes
Exclusion Criteria
- •younger than 18 years old
- •women of child bearing potential
Outcomes
Primary Outcomes
Ocular Color Doppler Imaging
Time Frame: 8 AM; 8 PM
Color Doppler Imaging * Nasal post ciliary artery (NPCA) * Temporal posterior ciliary artery (TPCA) * Ophthalmic artery (OA) * Central retinal artery (CRA)
Secondary Outcomes
- IOP, BP, OPP (mean, fluctuations, amplitude)(8 AM-12AM-4PM-8PM)