NCT00817440已完成不适用
Effects of Fasting and Exercise on Insulin and GH Signaltransduction in Muscle and Fat
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Growth hormone and insulin signal pathways
研究概览
简要总结
Hypothesis: under fasting there will primarily be an activation of growth hormone(GH) signalpathways and a inhibition of insulin signalpathways, and the opposite will happen under physical activity.
Primarily we will investigate markers for GH and insulin signaltransduction in muscle- and fat-biopsies after fasting for 72 hours and after 1 hour of ergometer-cycling at 65% Vo2max.
In addition to this we will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy men
- •Body mass index (BMI) 20-26
- •age 18-45 years
排除标准
- •any kind of disease
- •any use of medicine
结局指标
主要结局
Growth hormone and insulin signal pathways
时间窗: 30 min
次要结局
- aminoacid and glucose turnover(4 hours)
研究者
研究点 (2)
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