Growth Hormone During Fasting.Signaltransduktion in Muscle and Adipose Tissue and Changes in Intrahepatic Lipid Content
- Registration Number
- NCT00476879
- Lead Sponsor
- University of Aarhus
- Brief Summary
The purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.
- Detailed Description
During fasting the human body is known to metabolize relatively large amounts of fat, in the expense of proteins and glucose. Partly this shift in metabolism is caused by increasing GH secretion, but exactly how growth hormone exerts these effects remains to be further investigated.
10 healthy lean young men are studied at 4 different occasions in a randomized single-blinded cross-over study. 1: after 12 hours of fasting + GH bolus, 2: after 36 hours of fasting + GH bolus, 3: after 36 hours + saline, 4: after 36 hours of fasting + Somavert.
Aim:
* to study the signal transduction in muscle and fat tissue
* to study the metabolism during fasting
* to study the intrahepatic fat content using magnetic resonance techniques
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 10
- male
- healthy
- age 20 - 40 years of age
- BMI 20 -25
- uses any medication
- drinks more than 21 units of alcohol per
- is claustrophobic
- carries any magnetic devices
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 2 Somatropin and pegvisomant 36 hours of fasting and a GH bolus 3 Somatropin and pegvisomant 36 hours of fasting and Pegvisomant 4 Somatropin and pegvisomant 36 hours of fasting and NaCl injection 1 Somatropin and pegvisomant 12 hours of fasting and a GH bolus
- Primary Outcome Measures
Name Time Method insulin sensitivity 36 hours of fasting changes in intrahepatic lipid content 12 and 36 hours of fasting. respectively changes in respiratory quotient 36 hours of fasting changes in intracellular signaling during fasting 36 hours metabolism 36 hours of fasting forearm metabolism 36 hours of fasting
- Secondary Outcome Measures
Name Time Method Changes in grelin 36 hours of fasting changes in FFA 36 hours of fasting changes in leptin, adiponektin, cortisol, catecholamine, glucagon, carbamide, palmitate 36 hours of fasting
Trial Locations
- Locations (1)
Medical department M, Arhus Sygehus, Region midtjylland
🇩🇰Aarhus, Denmark
Medical department M, Arhus Sygehus, Region midtjylland🇩🇰Aarhus, Denmark