Effect of Growth Hormone on Insulin Signaling in Muscle Tissue

Not Applicable

Completed

• Conditions: Insulin Resistance
• Interventions: Device: Physiological Bolus of Growth Hormone

• Registration Number: NCT00477997
• Lead Sponsor: University of Aarhus

Brief Summary

The purpose of this study is to examine the effects of a physiological bolus of growth hormone on insulin signaling pathways in muscle tissue in healthy lean men.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-05
• Study First Submitted: 2007-05-23
• Study First Submitted QC: 2007-05-23
• Study First Posted: 2007-05-24
• Primary Completion: 2008-04
• Study Completion: 2008-08
• Status Verified: 2009-04
• Last Update Submitted: 2009-04-20
• Last Update Posted: 2009-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

• Male
• Healthy
• Age between 18 and 30 years
• BMI ≤ 26

Exclusion Criteria

• Known present disease including diabetes mellitus
• BMI > 26
• Uses any medication
• Consumes > 21 units of alcohol per week

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
1	Physiological Bolus of Growth Hormone	Saline bolus + OGTT
2	Physiological Bolus of Growth Hormone	GH-bolus and OGTT
3	Physiological Bolus of Growth Hormone	GH-bolus

Primary Outcome Measures

Name	Time	Method
PI3-kinase activity i muscle tissue	2 hours

Secondary Outcome Measures

Name	Time	Method
Growth Hormone Signaling Proteins in Muscle Tissue and other Insulin Signaling Proteins in Muscle Tissue	2 hours

Trial Locations

Locations (1)

Department M (endocrinology and diabetes); 🇩🇰 Aarhus, Denmark