Negative Predictive Value and NIC of Beta-Lactam Antibiotics.
- Conditions
- Allergy
- Registration Number
- NCT04126096
- Lead Sponsor
- Mayo Clinic
- Brief Summary
The researchers are trying to evaluate how much medication is required for allergy skin testing and to determine the likelihood that patients with a negative test truly don't have an allergy to the tested drug of skin testing to commonly used antibiotics.
- Detailed Description
This study will be a prospective study to accurately determine the negative predictive value of skin testing with beta lactam containing antibiotics other than penicillin .
It is hypothesized that the concentrations that should be used for beta lactams are actually much lower than previously recommended and that the higher incidence of identifiable beta lactam induced allergic reactions during anesthesia in the past may be due to irritation of the skin rather than a true allergic reaction (false positives).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 747
- All adults > or = to 18 y/o undergoing surgery
- Minors under the age of 18 y/o, Adults unable to consent, or those Adults with previous allergic reaction history during previous surgeries.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Non-Irritant Concentrations to common beta lactam containing antibiotics other than penicillin 1 Year Determine the NIC to common beta lactam containing antibiotics
- Secondary Outcome Measures
Name Time Method Negative Predictive Value of Intradermal Skin Testing to commonly used beta lactam containing antibiotics other than penicillin 1 Year Determine Negative Predictive Value of Intradermal Skin Testing to commonly used beta lactam containing antibiotics
Trial Locations
- Locations (2)
Mayo Clinic in Florida
🇺🇸Jacksonville, Florida, United States
Mayo Clinic
🇺🇸Jacksonville, Florida, United States
Mayo Clinic in Florida🇺🇸Jacksonville, Florida, United States